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It’s best to take Imitrex at the start of a migraine episode. Be sure to give the injection in the center of the muscles where it is thickest. This product is available in the following dosage forms: Powder for Solution Solution. The site where a subcutaneous injection is given should contain sufficient fatty tissue to avoid the needle hitting a muscle, bone, or blood vessel. Upper Arm: Uncover the arm to the shoulder. Do not warm up using a heat source such as hot water or a microwave. Give the injection halfway between the spine and the side. 71% of reviewers reported a positive experience, while 13% reported a negative experience. Also, do not lie down for about 15 to 30 minutes after taking it. Below your ribs and above your hip bones, at least 2 inches (5 centimeters) away from your belly button Imitrex has an average rating of 7. Methylprednisolone is a corticosteroid (cortisone-like medicine or steroid). Re: What is the best place to take Imitrex injection? 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